AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer
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چکیده
منابع مشابه
AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer
The basic helix-loop-helix transcription factor AP4/TFAP4/AP-4 is encoded by a c-MYC target gene and displays up-regulation concomitantly with c-MYC in colorectal cancer (CRC) and numerous other tumor types. Here a genome-wide characterization of AP4 DNA binding and mRNA expression was performed using a combination of microarray, genome-wide chromatin immunoprecipitation, next-generation sequen...
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Ubiquitin specific peptidase 22 (USP22), a putative cancer stem cell marker, is overexpressed in liver metastases of colorectal cancer (CRC). However, the mechanism by which USP22 promotes CRC metastasis remains largely unknown. Here, we report that USP22 and AP4 are simultaneously overexpressed during TGF-β1-induced CRC cell epithelial-mesenchymal transition (EMT). USP22 up-regulation enhances...
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ژورنال
عنوان ژورنال: The Journal of Cell Biology
سال: 2013
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.2017oia33